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The metal

The metallothionein trap

Copper

Overview

Copper is an essential trace mineral used by enzymes that power cellular energy (cytochrome-c oxidase), defend against oxidative stress (Cu/Zn-superoxide dismutase), and support connective tissue and myelin integrity (lysyl oxidase, dopamine-β-hydroxylase). Goldmind:Focus includes 0.9 mg/day copper as a gentle, highly bioavailable bisglycinate chelate.

Goldmind:Focus provides daily zinc for focus support. Long-term zinc use can lower copper absorption by inducing intestinal metallothionein, a protein that binds copper more avidly than zinc; the bound copper is then lost as cells slough from the gut. Over time, this imbalance can lead to hypocupremia (classically: anemia, neutropenia, and sensory neuropathy) in susceptible individuals. Supplying 0.9 mg/day copper (the adult RDA) alongside zinc maintains mineral balance and reduces the risk that zinc intake nudges copper status downward.

How it supports balance -- mechanisms (overview)
• Metallothionein “gatekeeping”: Excess zinc up-regulates metallothionein in enterocytes, which preferentially traps copper → reduced copper absorption. Providing copper helps keep systemic copper availability within the normal range.
• Enzymatic coverage at the RDA: 0.9 mg/day supports the copper-dependent enzymes involved in mitochondrial ATP production, antioxidant defense (Cu/Zn-SOD), neurotransmitter synthesis, and collagen/myelin maintenance.
• Form matters: Bisglycinate chelates are designed for good GI tolerability and bioavailability, minimizing the risk of gastric upset sometimes seen with inorganic salts.


Dose & safety context
• Dose: 0.9 mg/day (adult RDA).
• Balance: Pairs with the product’s zinc to maintain a prudent Zn:Cu balance typical of evidence-based multis.
• Safety: The U.S. adult UL for copper is 10 mg/day; individuals with disorders of copper metabolism (e.g., Wilson’s disease) should consult their clinician before use.


References
• Fosmire GJ. Zinc toxicity. American Journal of Clinical Nutrition. 1990;51(2):225–227.
• Willis MS, Monaghan SA, Miller ML, et al. Zinc-induced copper deficiency: a report of three cases initially diagnosed as myelodysplastic syndrome. American Journal of Clinical Pathology. 2005;123(1):125–131.
• Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press; 2001. (Copper RDA = 0.9 mg/day; Zinc UL = 40 mg/day.)
• National Institutes of Health, Office of Dietary Supplements. Copper — Fact Sheet for Health Professionals. Updated 2022. (Summary of functions, RDA/UL, and deficiency manifestations.)