Zinc is a cofactor in neurotransmitter synthesis and signaling and supports normal brain function. Deficiency is associated with changes in cognitive and psychological function; maintaining adequate zinc status is part of the foundation for attention and memory. (We dose within typical dietary-supplement ranges and below upper limits.)

It is a trace mineral and gene regulator which also acts as an antioxidant (superoxide dismutase). It regulates dopamine synthesis and receptor activity, and plays a role in LTP–the process underlying memory formation. Cognitive boosts (d≈0.1) likely reflect correcting deficiency rather than benefits from supra-normal levels. More is not better–too much zinc can lead to worsened memory (in mice) and copper deficiency.

Citation:
Warthon-Medina, M, et al. Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis. Eur J Clin Nutr 69, 649–661 (2015).